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Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
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Circulating microRNA Profile throughout the menstrual cycle.

Kadri Rekker1, Merli Saare, Anne Mari Roost

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Summary

Menstrual cycle changes do not significantly alter circulating microRNA (miRNA) levels in healthy women. Most plasma miRNAs originate from blood cells, with hsa-miR-451a being highly abundant.

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Area of Science:

  • Biochemistry
  • Genetics
  • Physiology

Background:

  • Physiological variables like age and gender influence circulating microRNA (miRNA) expression.
  • The menstrual cycle involves significant physiological changes in women, potentially impacting miRNA profiles.

Purpose of the Study:

  • To investigate plasma miRNA profiles in healthy women throughout their menstrual cycle.
  • To identify circulating miRNAs originating from blood cells.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) using Exiqon Human Panel I assays.
  • Analysis of plasma and whole blood miRNA expression across four menstrual cycle time-points in nine women.

Main Results:

  • Circulating miRNA expression levels showed no significant alterations across menstrual cycle phases.
  • Plasma miRNA profiles varied considerably among individuals, not due to the menstrual cycle.
  • Majority of plasma miRNAs were identified as originating from blood cells, with hsa-miR-451a being the most abundant.

Conclusions:

  • Menstrual cycle-related physiological changes do not measurably affect circulating miRNA expression levels in healthy women.
  • Blood cells are a primary source of circulating miRNAs found in plasma.