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Updated: May 5, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Tumor-targeting vaccination instructs graft-vs.-tumor immune responses
Teresa Manzo1, Rodrigo Hess Michelini, Tabea Sturmheit
1Lymphocyte Activation Unit; Program in Immunology and Bio-Immunotherapy of Cancer; Division of Immunology, Transplantation and Infectious Disease; San Raffaele Scientific Institute; Milan, Italy ; Università Vita-Salute San Raffaele; Milan, Italy.
Abstract:
Anticancer vaccines hold the potential to promote tumor eradication by immune effector cells. We have recently found dendritic cell-based vaccines to instruct graft-vs.-tumor responses following allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusion. Vaccination was essential to elicit the intratumoral expression of interferon γ, promote local inflammation, and stimulate therapeutic T-cell infiltration.
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