Related Experiment Video
Updated: May 5, 2026
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
The Effect of EMLA Cream on Patient-Controlled Analgesia with Remifentanil in ESWL Procedure: A Placebo-Controlled
Arzu Acar1, Elvan Erhan, M Nuri Deniz
1Department of Anaesthesiology and Reanimation, School of Medicine, Ege University, Izmir, Turkey.
Background:
To alleviate stinging pain in the skin entry area and visceral discomfort in patients who are undergoing ESWL.
Objectives:
This study was designed to investigate the effectiveness of the EMLA cream in combination with remifentanil patient-controlled analgesia (PCA) in patients undergoing ESWL treatment.
Patients And Methods:
Sixty patients were divided into two double-blind randomized groups. Those in the first group were administered 3-5mm of EMLA 5% cream on a marked area; the second group received, as a placebo, a cream with no analgesic effect in the same amount. All patients were administered a remifentanil bolus with a PCA device. Arterial blood pressure, oxygen saturation, and respiratory rate were recorded throughout the procedure; postoperative side effects, agitation, and respiratory depression were measured after. Visual Analogue Scale (VAS) scores were taken preoperatively, perioperatively, directly postoperatively, and 60 minutes subsequent to finishing the procedure.
Results:
There were no statistically significant differences in the frequency of PCA demands and delivered boluses or among perioperative VAS. No significant side effects were noted. Patient satisfaction was recorded high in both groups.
Conclusions:
EMLA cream offered no advantage over the placebo cream in patients undergoing ESWL with remifentanil PCA.
