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Updated: May 5, 2026

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
Published on: November 12, 2019
A simple algorithm to generate firing times for leaky integrate-and-fire neuronal model
Aniello Buonocore1, Luigia Caputo, Enrica Pirozzi
1Dipartimento di Matematica e Applicazioni, Università di Napoli Federico II, Via Cintia, Napoli, Italy. aniello.buonocore@unina.it.
Abstract:
A method to generate first passage times for a class of stochastic processes is proposed. It does not require construction of the trajectories as usually needed in simulation studies, but is based on an integral equation whose unknown quantity is the probability density function of the studied first passage times and on the application of the hazard rate method. The proposed procedure is particularly efficient in the case of the Ornstein-Uhlenbeck process, which is important for modeling spiking neuronal activity.
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