Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

10-year clinical outcomes of subthalamic nucleus versus pallidal deep brain stimulation for Parkinson's disease: VA/NINDS CSP #468F.

Frontiers in neurology·2026

Same author

Rethinking Parkinson's disease genetics in the precision medicine era: why genomic diversity matters?

Frontiers in genetics·2026

Same author

Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson's disease.

Frontiers in immunology·2025

Same author

Diagnostic work up when suspecting early onset Parkinson disease (EOPD). Recommendations from the MDS EOPD study group.

Parkinsonism & related disorders·2025

Same author

Valbenazine for the treatment of chorea associated with Huntington's disease.

Expert opinion on pharmacotherapy·2024

Same author

Pregnancy in Dystonia or Tourette's Patients with DBS. Fourteen News Cases and a Review of the Literature.

Movement disorders clinical practice·2024

Search research articles

Related Experiment Video

Updated: May 5, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Deep brain stimulation in Parkinson's disease.

Raja Mehanna, Eugene C Lai¹

¹Department of Neurology, Houston Methodist Neurological Institute, 6560 Fannin, Suite 802, Houston 77030, TX, USA. eclai@tmhs.org.

Translational Neurodegeneration

|November 20, 2013

Summary

Levodopa helps Parkinson's disease, but motor complications arise. Deep brain stimulation is an option, yet its mechanism, optimal targets, and timing require further investigation.

Area of Science:

Neurology
Neurosurgery

Background:

Levodopa is the primary treatment for Parkinson's disease (PD) for 50 years.
Motor complications frequently develop within years of levodopa initiation.
Deep brain stimulation (DBS) is FDA-approved for PD adjunctive therapy.

Purpose of the Study:

To critically review the current literature on deep brain stimulation for Parkinson's disease.
To discuss the unresolved questions regarding DBS efficacy and application in PD management.

Main Methods:

Comprehensive literature search of existing studies on deep brain stimulation in Parkinson's disease.
Critical analysis of the mechanism of action, target selection, and surgical timing of DBS.

Main Results:

More Related Videos

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Related Experiment Videos

Last Updated: May 5, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Deep brain stimulation is effective in managing motor complications of Parkinson's disease.
Significant debate persists regarding the optimal surgical target and timing for DBS implantation.
The precise neurobiological mechanisms underlying DBS effects in PD remain incompletely understood.

Conclusions:

Deep brain stimulation is a valuable tool for managing Parkinson's disease motor complications.
Further research is needed to elucidate the mechanisms, optimize targeting, and determine the ideal timing for DBS surgery.
Personalized treatment strategies incorporating DBS may improve outcomes for Parkinson's disease patients.