Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Humoral immunodeficiency.

R H Buckley

    Clinical Immunology and Immunopathology
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Humoral immunodeficiency syndromes involve antibody deficiencies, often leading to recurrent infections. Early diagnosis and immunoglobulin replacement therapy are crucial for managing these conditions and preventing severe complications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term outcome of non-ablative booster BMT in patients with SCID.

    Bone marrow transplantation·2013
    Same author

    Population prevalence of diagnosed primary immunodeficiency diseases in the United States.

    Journal of clinical immunology·2007
    Same author

    The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID).

    Journal of clinical immunology·2006
    Same author

    Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).

    Vox sanguinis·2003
    Same author

    Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.

    Molecular cell·2001
    Same author

    Cutaneous complications of BCG vaccination in infants with immune disorders: two cases and a review of the literature.

    Pediatric dermatology·2001
    Same journal

    Mechanisms of virus replication, persistence, and regulation of immune responses.

    Clinical immunology and immunopathology·2020
    Same journal

    Cumulative subject index for volumes 86-89

    Clinical immunology and immunopathology·1998
    Same journal

    D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease.

    Clinical immunology and immunopathology·1998
    Same journal

    Characterization of gastric Na+/I- symporter of the rat.

    Clinical immunology and immunopathology·1998
    Same journal

    CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.

    Clinical immunology and immunopathology·1998
    Same journal

    Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus.

    Clinical immunology and immunopathology·1998
    See all related articles

    Area of Science:

    • Immunology
    • Genetics

    Background:

    • Humoral immunodeficiency syndromes encompass a range of congenital or acquired antibody deficiencies.
    • These conditions are characterized by reduced levels of one or more immunoglobulin classes.
    • While often associated with recurrent infections, some types like selective IgA deficiency may present with minimal symptoms.

    Purpose of the Study:

    • To review the characteristics of humoral immunodeficiency syndromes.
    • To discuss the genetic basis and cellular defects involved.
    • To emphasize the importance of early diagnosis and treatment.

    Main Methods:

    • Review of existing literature on humoral immunodeficiency.
    • Analysis of clinical presentations and genetic inheritance patterns.
    • Discussion of B-cell function and maturation abnormalities.

    Related Experiment Videos

    Main Results:

    • Humoral immunodeficiency is more common than cellular immunodeficiency.
    • B-cell maturation and intrinsic B-cell malfunction are implicated in most defects.
    • The precise primary biologic errors remain largely unknown.
    • X-linked agammaglobulinemia shows heterogeneity, suggesting complex genetic underpinnings.

    Conclusions:

    • Early identification of B-cell deficiencies is critical.
    • Prompt immunoglobulin replacement therapy can prevent severe infections and long-term damage.
    • Effective management allows patients to lead relatively normal lives.