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Fe-salphen complexes from intracellular pH-triggered degradation of Fe3O4@Salphen-InIII CPPs for selectively killing
Shuai Xu1, Jing Liu2, Dian Li1
1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai 200433, PR China.
Abstract:
We propose a modular synthetic strategy to constitute metallosalphen prodrugs in the form of coordination polymer nanoparticles, comprising magnetite nanocrystal colloidal cluster as core and salphen-In(III) coordination polymer as shell. These composite nanoparticles are not only equipped with intense photoluminescence, sensitive magnetic responsiveness and pH-dependent degradability, but also serve as prodrugs to accomplish intercellular conversion from non-toxic nanoparticles (Fe3O4@Salphen-In(III)) to pharmacologically active complexes (Fe-salphen), allowing to specifically inhibit the proliferation of A549 cancer cells via caspase activation.
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