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Toscana virus infections: a case series from France

J Dupouey1, L Bichaud1, L Ninove1

  • 1UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005 Marseille, France; IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France.

The Journal of Infection
|November 20, 2013
PubMed

Insights

Toscana virus (TOSV), a sandfly-borne pathogen, caused symptomatic infections in Marseille, France. Most cases presented with fever and neurological symptoms, with all patients recovering fully.

Area of Science:

  • Infectious Diseases
  • Virology
  • Epidemiology

Background:

  • Toscana virus (TOSV) is a neglected sandfly-borne pathogen prevalent in Mediterranean regions.
  • Clinical descriptions of TOSV infections are limited, primarily consisting of case reports.

Observation:

  • A retrospective study analyzed symptomatic TOSV infections in hospitalized patients in Marseille, France (2004-2011).
  • Seventeen probable or confirmed cases were identified, with a seasonal peak from June to September.

Findings:

  • All patients exhibited fever and neurological manifestations, including aseptic meningitis, encephalitis, and muscular symptoms.
  • Diagnostic methods confirmed TOSV infection through IgM detection, neutralization tests, and RT-PCR in cerebrospinal fluid.
  • All observed cases had a favorable outcome.

Implications:

  • This study highlights the clinical spectrum of TOSV infections in a non-endemic area.
  • It underscores the importance of considering TOSV in patients with febrile neurological illness, especially during warmer months.
  • Further research is needed to understand the full public health impact of this neglected virus.
Keywords:
ArbovirusEmergingFeverMeningitisPhlebovirus

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