P100 amplitude variability of the pattern visual evoked potential

This study quantifies the amplitude variability of the pattern visual evoked potential (P-VEP) and compares this variability between the two eyes and between individual runs recorded in the typical clinical laboratory. Cooperative adults were studied in order to obtain measurements under optimal conditions. Average P100 amplitudes of 10 runs for one eye were essentially equal to average P100 amplitudes of the other eye, as were the variances. Mean amplitude ratio (the smaller amplitude divided by the larger amplitude) was 0.91. With a group mean P100 amplitude of 10.06 microV, standard deviation for intrasubject data was 1.84, and for intersubject data was 3.75. Therefore, most of the amplitude variability between the two eyes is due to run-to-run variability. A minimum of 3 runs (100 stimuli each) and an optimum of 5 runs should be recorded before making an evaluation.