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Risk factor analysis of calcification in aortic and mitral valves in maintenance peritoneal dialysis patients

Chunyuan Wang1, Linsen Jiang, Sheng Feng

  • 1Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.

Kidney & Blood Pressure Research
|November 20, 2013
PubMed

Insights

Cardiac valve calcification is common in maintenance peritoneal dialysis (MPD) patients. Key risk factors for aortic valve calcification (AVC) and mitral valve calcification (MVC) include age, diabetes, and calcium-phosphorus product.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Cardiac valve calcification is a significant complication in patients undergoing maintenance peritoneal dialysis (MPD).
  • Understanding the risk factors associated with aortic valve calcification (AVC) and mitral valve calcification (MVC) is crucial for patient management.

Purpose of the Study:

  • To identify and analyze the independent risk factors contributing to calcification in the aortic and mitral valves of MPD patients.
  • To determine the prevalence and specific risk profiles for AVC and MVC in this patient population.

Main Methods:

  • A cohort of 117 MPD patients with over 18 months of dialysis were enrolled.
  • Echocardiography was used to assess cardiac valve calcification, alongside recording biochemical and dialysis-related data.
  • Multivariate logistic regression analysis was employed to identify independent risk factors for AVC and MVC.

Main Results:

  • 41 out of 117 MPD patients exhibited cardiac valve calcification (38 AVC, 17 MVC).
  • Independent risk factors for AVC included age, diabetes history, calcium-phosphorus product, and prealbumin levels.
  • Independent risk factors for MVC included age, diabetes history, calcium-phosphorus product, prealbumin levels, and high-density lipoprotein levels.

Conclusions:

  • The incidence of cardiac valve calcification, particularly AVC, is high in MPD patients.
  • Age, diabetes history, elevated calcium-phosphorus product, and hypo-prealbuminemia are significant independent risk factors for AVC and MVC in MPD patients.
Abstract

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