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Updated: May 5, 2026

Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Marked differences in GPs' diagnosis of pneumonia between Denmark and Spain: a cross-sectional study
Sarah Friis Christensen1, Lars Christian Jørgensen, Gloria Cordoba
1Section of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Background:
In patients with lower respiratory tract infections (LRTIs) it is a challenge to identify who should be treated with antibiotics. According to international guidelines, antibiotics should be prescribed to patients with suspected pneumonia while acute bronchitis is considered a viral infection and should, generally, not be treated with antibiotics. Overdiagnosis of pneumonia in patients with LRTIs may lead to antibiotic overprescribing.
Aims:
To investigate the prevalence of presumed pneumonia in patients with LRTI in two countries with different antibiotic prescribing rates (Denmark and Spain) and to compare which symptoms and clinical tests are of most importance for the GP when choosing a diagnosis of pneumonia rather than acute bronchitis.
Methods:
A cross-sectional study including GPs from Denmark and Spain was conducted as part of the EU-funded project HAPPY AUDIT. A total of 2,698 patients with LRTI were included.
Results:
In Denmark, 47% of the patients with LRTI were classified with a diagnosis of pneumonia compared with 11% in Spain. In Spain, fever and a positive x-ray weighted significantly more in the diagnosis of pneumonia than in Denmark. Danish GPs, however, attached more importance to dyspnoea/polypnoea and C-reactive protein levels >50mg/L. None of the other typical symptoms of pneumonia had a significant influence.
Conclusions:
Our results indicate that GPs' diagnostic criteria for pneumonia differ substantially between Denmark and Spain. The high prevalence of pneumonia among Danish patients with LRTI may indicate overdiagnosis of pneumonia which, in turn, may lead to antibiotic overprescribing.
Insights
Diagnoses of pneumonia in lower respiratory tract infections (LRTI) varied significantly between Denmark and Spain. Differences in diagnostic criteria may contribute to antibiotic overprescribing, particularly in Denmark.
Area of Science:
- General Practice
- Infectious Diseases
- Antibiotic Stewardship
Background:
- Identifying appropriate antibiotic use for lower respiratory tract infections (LRTI) is challenging.
- International guidelines differentiate treatment for pneumonia versus acute bronchitis.
- Overdiagnosis of pneumonia can lead to unnecessary antibiotic prescribing.
Purpose of the Study:
- Compare pneumonia prevalence in LRTI patients between Denmark and Spain, countries with differing antibiotic prescribing rates.
- Identify key symptoms and clinical findings influencing general practitioners' (GPs) pneumonia diagnosis over acute bronchitis.
Main Methods:
- Cross-sectional study within the EU-funded HAPPY AUDIT project.
- Inclusion of 2,698 patients diagnosed with LRTI.
- Data collected from GPs in Denmark and Spain.
Main Results:
- Pneumonia prevalence in LRTI was 47% in Denmark versus 11% in Spain.
- Spanish GPs prioritized fever and positive X-ray for pneumonia diagnosis.
- Danish GPs placed greater importance on dyspnea/tachypnea and elevated C-reactive protein (>50mg/L).
Conclusions:
- Significant differences exist in GPs' diagnostic criteria for pneumonia between Denmark and Spain.
- High pneumonia prevalence in Danish LRTI patients suggests potential overdiagnosis.
- This overdiagnosis may contribute to increased antibiotic prescribing rates.
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