Investigation of enhanced ion abundances from a carrier process in high-performance liquid chromatography particle
T A Bellar1, T D Behymer, W L Budde
1Office of Research and Development USEPA-Cincinnati, Environmental Monitoring Systems Laboratory, U.S. Environmental Protection Agency, 26 W. Martin Luther King Drive, 45268, Cincinnati, OH, USA.
Abstract:
Enhancements in ion abundances in high-performance liquid chromatography (HPLC) particle beam (PB) mass spectrometry were observed during coelution or when certain substances (e.g., ammonium acetate) were added to the mobile phase during a reverse-phase gradient elution HPLC separation. These enhancements were observed with two commercial PB interfaces and a variety of compounds generally not amenable to separation by gas chromatography. The enhancements are attributed to both improved chromatographic efficiency and a PB carrier process.
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