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Updated: May 5, 2026

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
Oligopeptide fragmentation viewed as constant neutral loss
C Fenselau1, C M Murphy, R J Cotter
1Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 21228, Baltimore, MD.
Abstract:
Spectra were recorded of all fragment ions formed by elimination of 28-u neutral fragments in fast atom bombardment spectra of peptides in the mass range 1000-1800 u, This approach can provide less complex spectra than either conventionally scanned spectra or product ion scans from collisionaIly activated four-sector experiments, and spectra that contain information that is both overlapping and complementary to those from the other techniques. Constant neutral loss spectra may provide a reading frame for distinguishing sequence ion series in tandem or single analyzer spectra.
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