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Related Concept Videos

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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Mass Spectrum: Interpretation01:24

Mass Spectrum: Interpretation

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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
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Mass Analyzers: Common Types01:19

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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Mass Spectrometers01:16

Mass Spectrometers

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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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Related Experiment Video

Updated: May 5, 2026

Spatial Separation of Molecular Conformers and Clusters
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Beam deflection for temporal encoding in time-of-flight mass spectrometry.

G E Yefchak1, G A Schultz, J Allison

  • 1Department of Chemistry, Michigan State University, 48824, East Lansing, Ml.

Journal of the American Society for Mass Spectrometry
|November 20, 2013
PubMed
Summary
This summary is machine-generated.

Beam deflection techniques enhance resolving power in time-of-flight mass spectrometry (TOFMS) for gas chromatography (GC/MS) applications. This method allows for greater ionization mode flexibility and improved performance compared to conventional pulsed ion sources.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Chromatography

Background:

  • Conventional time-of-flight mass spectrometry (TOFMS) using pulsed ion sources often lacks sufficient resolving power for demanding applications like gas chromatography-mass spectrometry (GC/MS).
  • Achieving high resolving power is critical for accurate identification and quantification of analytes in complex mixtures.

Purpose of the Study:

  • To explore the theoretical and experimental aspects of beam deflection techniques for time encoding in TOFMS with continuous ion sources.
  • To evaluate the suitability of beam deflection for enhancing resolving power in GC/MS applications.
  • To compare the performance of a GC-beam deflection-TOFMS system with time-array detection against scanning mass spectrometers.

Main Methods:

  • Investigated theoretical principles of ion beam deflection for time encoding.
  • Conducted experimental validation of the beam deflection approach.
  • Combined gas chromatography with beam deflection-time-of-flight mass spectrometry (GC-beam deflection-TOFMS) and employed time-array detection.
  • Compared system capabilities with conventional scanning mass spectrometers.

Main Results:

  • Ion source conditions were found to not impact resolving power when using beam deflection.
  • Theoretical predictions for resolving power with beam deflection closely matched experimentally determined values.
  • The GC-beam deflection-TOFMS system demonstrated satisfactory resolving power for GC/MS applications.

Conclusions:

  • Beam deflection techniques offer a viable method for improving resolving power in TOFMS, particularly for GC/MS.
  • This approach enables the use of a wider range of ionization modes without compromising performance.
  • The evaluated GC-beam deflection-TOFMS system shows competitive capabilities compared to scanning mass spectrometers.