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Thrombophilia testing in children: a 7 year experience

A Mahajerin1, P Obasaju, G Eckert

  • 1Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, Indiana.

Pediatric Blood & Cancer
|November 20, 2013
PubMed

Insights

Pediatric venous thromboembolism (VTE) testing shows low thrombophilia rates in both inpatient and outpatient settings. Protein C deficiency was more common in outpatients, while central lines were linked to less testing in inpatients.

Area of Science:

  • Pediatric Hematology
  • Thrombosis Research
  • Clinical Diagnostics

Background:

  • Increasing incidence of pediatric venous thromboembolism (VTE).
  • Need to understand thrombophilia testing patterns in pediatric VTE cases.
  • Evaluation of inpatient versus outpatient testing strategies.

Purpose of the Study:

  • To examine thrombophilia testing results in children with VTE.
  • To compare testing patterns between inpatient and outpatient pediatric VTE populations.
  • To identify factors associated with thrombophilia testing in pediatric VTE.

Main Methods:

  • Retrospective study of children (0-20 years) with VTE from Jan 2005 to Apr 2012.
  • Inclusion criteria: VTE confirmed by imaging.
  • Thrombophilia diagnosis based on specific laboratory and genetic markers.

Main Results:

  • 392 pediatric VTE patients met inclusion criteria.
  • 157/239 inpatients and all 153 outpatients underwent thrombophilia testing.
  • Protein C deficiency was significantly higher in outpatients; central venous lines were associated with less testing in inpatients.

Conclusions:

  • Pediatric VTE populations exhibit low overall thrombophilia rates.
  • Testing patterns and specific deficiencies vary between inpatient and outpatient settings.
  • Further research is needed to define optimal thrombophilia testing in pediatric VTE.
Abstract

Keywords:
pediatric hematology/oncologythrombophiliathrombosis

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