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Thrombophilia testing in children: a 7 year experience
A Mahajerin1, P Obasaju, G Eckert
1Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, Indiana.
Pediatric Blood & Cancer
|November 20, 2013
Summary
Pediatric venous thromboembolism (VTE) testing shows low thrombophilia rates in both inpatient and outpatient settings. Protein C deficiency was more common in outpatients, while central lines were linked to less testing in inpatients.
Area of Science:
- Pediatric Hematology
- Thrombosis Research
- Clinical Diagnostics
Background:
- Increasing incidence of pediatric venous thromboembolism (VTE).
- Need to understand thrombophilia testing patterns in pediatric VTE cases.
- Evaluation of inpatient versus outpatient testing strategies.
Purpose of the Study:
- To examine thrombophilia testing results in children with VTE.
- To compare testing patterns between inpatient and outpatient pediatric VTE populations.
- To identify factors associated with thrombophilia testing in pediatric VTE.
Main Methods:
- Retrospective study of children (0-20 years) with VTE from Jan 2005 to Apr 2012.
- Inclusion criteria: VTE confirmed by imaging.
- Thrombophilia diagnosis based on specific laboratory and genetic markers.
Main Results:
- 392 pediatric VTE patients met inclusion criteria.
- 157/239 inpatients and all 153 outpatients underwent thrombophilia testing.
- Protein C deficiency was significantly higher in outpatients; central venous lines were associated with less testing in inpatients.
Conclusions:
- Pediatric VTE populations exhibit low overall thrombophilia rates.
- Testing patterns and specific deficiencies vary between inpatient and outpatient settings.
- Further research is needed to define optimal thrombophilia testing in pediatric VTE.
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