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Non-Gaussian diffusion-weighted imaging for assessing diurnal changes in intervertebral disc microstructure.

Masaki Katsura1, Yuichi Suzuki, Junichi Hata

  • 1Department of Radiology Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Journal of Magnetic Resonance Imaging : JMRI
|November 20, 2013
PubMed
Summary
This summary is machine-generated.

Non-Gaussian diffusion-weighted imaging (q-space imaging [QSI]) can detect diurnal changes in intervertebral disc (IVD) microstructure. Root mean square displacement (RMSD) and apparent kurtosis coefficient (AKC) values from QSI may serve as biomarkers for these IVD changes.

Keywords:
diurnal changesintervertebral discnon-Gaussian diffusion-weighted imagingq-space imaging

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Area of Science:

  • Biomedical Imaging
  • Radiology
  • Musculoskeletal System

Background:

  • Intervertebral disc (IVD) health is crucial for spinal function.
  • Understanding diurnal variations in IVD microstructure is important for assessing spinal health.
  • Non-Gaussian diffusion imaging techniques offer novel insights into tissue microstructure.

Purpose of the Study:

  • To evaluate the utility of q-space imaging (QSI) for quantifying diurnal changes in human IVD microstructure.
  • To determine if specific QSI metrics can serve as biomarkers for these daily microstructural alterations.

Main Methods:

  • Fifteen healthy male subjects underwent 3 Tesla (T) MR imaging of their IVDs in the morning and evening.
  • T2 mapping and QSI data were acquired, calculating apparent diffusion coefficient (ADC), root mean square displacement (RMSD), and apparent kurtosis coefficient (AKC).
  • QSI parameters were compared between morning and evening sessions to assess diurnal variations.

Main Results:

  • Significant decreases in T2, ADC, and RMSD values were observed in the evening compared to the morning.
  • Apparent kurtosis coefficient (AKC) values significantly increased in the evening relative to the morning.
  • These diurnal changes indicate alterations in IVD microstructure throughout the day.

Conclusions:

  • QSI-derived root mean square displacement (RMSD) and apparent kurtosis coefficient (AKC) show significant diurnal variations in IVDs.
  • RMSD and AKC hold potential as sensitive biomarkers for detecting diurnal microstructural changes in the intervertebral disc.
  • This study highlights QSI's capability in assessing dynamic microstructural changes within the IVD.