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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
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  1. Home
  3. Growth Properties Of Cardiac Stem Cells Are A Novel Biomarker Of Patients' Outcome After Coronary Bypass Surgery.
  1. Home
  3. Growth Properties Of Cardiac Stem Cells Are A Novel Biomarker Of Patients' Outcome After Coronary Bypass Surgery.

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Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery.

Domenico D'Amario1, Antonio M Leone, Antonio Iaconelli

  • 1Department of Cardiovascular Sciences, Catholic University of the Sacred Heart, Rome, Italy (D.D'A., A.M.L., A.I., N.L., M.G., M. Manchi, A. Severino, F.G., G.B., A.M., C.S., G.L.D.M., C.C., A. Siracusano, L.O., M. Massetti, F.C.); and Departments of Anesthesia and Medicine, and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.D'A., R.K., S.H.S., P.G., A.L., P.A.).

Circulation
|November 20, 2013

View abstract on PubMed

Summary
This summary is machine-generated.

Cardiac stem cell (CSC) growth reserve and insulin-like growth factor-1 predict bypass surgery outcomes in ischemic cardiomyopathy. These factors indicate how the heart will remodel after surgery, offering a new biomarker for patient stratification.

Keywords:
coronary artery diseasereceptor, IGF type 1stem cellstelomerasetelomereventricular remodeling

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Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Predicting bypass surgery efficacy in ischemic cardiomyopathy is challenging due to similar preoperative conditions but varied outcomes.
  • Cardiac stem cell (CSC) growth reserve and circulating cytokines are hypothesized to critically influence ventricular remodeling post-surgery.

Purpose of the Study:

  • To investigate the relationship between CSC growth kinetics and ventricular remodeling after bypass surgery.
  • To identify biomarkers for predicting patient outcomes in ischemic cardiomyopathy.

Main Methods:

  • Measured CSC growth kinetics (doubling time, telomere length, telomerase activity, IGF-1R expression) in 38 patients undergoing bypass surgery.
  • Assessed blood levels of IGF-1, HGF, and VEGF.
  • Correlated CSC function indices with changes in cardiac anatomy (wall thickness, chamber dimensions, mass-to-volume ratio, ejection fraction) pre- and post-surgery.

Main Results:

  • A strong correlation was observed between CSC function indices and cardiac anatomy changes.
  • Patients with retained CSC growth reserve did not exhibit negative ventricular remodeling.
  • High circulating IGF-1, HGF, and VEGF levels were noted preoperatively, suggesting their role in myocardial adaptation and vascularization.

Conclusions:

  • The telomere-telomerase axis, CSC doubling time, and IGF-1R expression, along with high circulating IGF-1, serve as novel biomarkers.
  • These biomarkers can predict the ventricular remodeling and clinical evolution of ischemic cardiomyopathy following revascularization.