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Updated: May 5, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Introduction of complementary foods and the relationship to food allergy
Kate E C Grimshaw1, Joe Maskell, Erin M Oliver
1RD, Clinical and Experimental Sciences Academic Unit, Mailpoint 803, Level F, South Academic Block, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, UK. kecg@soton.ac.uk.
Objectives:
To address questions regarding breastfeeding, complementary feeding, allergy development, and current infant-feeding recommendations.
Methods:
This was a nested, case-control within a cohort study in which mothers of 41 infants diagnosed with food allergy by the age of 2 years (according to double-blind, placebo-controlled food challenge) and their 82 age-matched controls kept prospective food diaries of how their infants were fed in the first year of life.
Results:
Infants who were diagnosed with food allergy by the time they were 2 years of age were introduced to solids earlier (≤16 weeks of age) and were less likely to be receiving breast milk when cow's milk protein was first introduced into their diet.
Conclusions:
This study supports the current American Academy of Pediatrics' allergy prevention recommendations and the European Society of Pediatric Gastroenterology, Hepatology and Nutrition recommendations on complementary feeding to not introduce solids before 4 to 6 months of age. It also supports the American Academy of Pediatrics' breastfeeding recommendations that breastfeeding should continue while solids are introduced into the diet and that breastfeeding should continue for 1 year, or longer, as mutually desired by mother and infant.
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