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Optimization of In - vitro Permeation Pattern of Ketorolac Tromethamine Transdermal Patches
Pintu Kumar De1, Subrata Mallick, Biswajit Mukherjee
1B . C . Roy College of Pharmacy and Allied Health Sciences , Bidhannagar , Durgapur , 713206, W . B . India .
Abstract:
The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surfacet opography of the patches was examined by scanning electron microscopy (SEM). The drug-polymer interaction studies were performed using Fourier transform infrared spectroscopic (FTIR) technique. A correlation between in - vitro drug-release and in - vitro skin permeation was established and the criterion of desirability was employed to optimize the formulation. The results of the physicochemical characterization and in - vitro permeation of the prepared patches were promising to formulate transdermal patches with PVP/EC combinations.
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