Related Experiment Video
Updated: May 5, 2026
07:27
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
25.7K
Olfactory dysfunction in persian patients suffering from parkinson's disease
Akbar Soltanzadeh1, Mehdi Shams, Hamid Noorolahi
1Neurology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran ; Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
Iranian Journal of Neurology
|November 20, 2013
Summary
Olfactory dysfunction is prevalent in Persian Parkinson disease (PD) patients, with impaired smell identification correlating with disease severity. Early olfactory testing may aid in PD diagnosis, especially in older adults.
Area of Science:
- Neurology
- Gerontology
- Otorhinolaryngology
Background:
- Olfactory dysfunction, including hyposmia/anosmia, is a common manifestation of aging and neurodegenerative disorders.
- Olfactory impairment is recognized as a non-motor symptom of Parkinson disease (PD).
Purpose of the Study:
- To investigate the extent of olfactory dysfunction in Persian patients diagnosed with Parkinson disease.
Main Methods:
- Seven common odors (rosewater, mint, lemon, garlic, coffee, vinegar) were used for olfactory testing.
- Participants identified and named odors presented to each nostril separately.
Main Results:
- 92 PD patients and 40 controls were assessed; PD patients showed significantly lower odor identification accuracy compared to controls.
- A significant negative correlation was found between odor identification scores and the Unified Parkinson Disease Rating Scale (UPDRS) scores.
- No significant correlation was observed between the duration of PD and olfactory function.
Conclusions:
- Smelling dysfunction is a significant issue in Persian PD patients, warranting further investigation into its causes.
- Olfactory dysfunction assessment may be valuable for early detection and management of Parkinson disease, particularly in the elderly.
Related Concept Videos
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:03Olfactory Receptors: Location and Structure
10.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.6K
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:24Parkinson Disease ll: Pathophysiology
34
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
34
01:24Parkinson Disease l: Introduction
28
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
28
01:25Olfaction
40.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
40.5K