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The effect of cyanosis on active clotting time during diagnostic catheterization

Akbar Molaei1, Majid Malaki, Shahram Sadegvand

  • 1Madani Heart Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Cardiovascular and Thoracic Research
|November 20, 2013
PubMed

Insights

Cyanosis does not impact active clotting time (ACT) after heparin. However, heparin’s effectiveness diminishes more rapidly in older children after 60 minutes.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Cardiac catheterization requires vigilant coagulation monitoring.
  • Heparin therapy is frequently used during these procedures.

Purpose of the Study:

  • To investigate factors influencing active clotting time (ACT) post-heparin administration.
  • To compare ACT in cyanotic versus non-cyanotic patients.

Main Methods:

  • 71 patients undergoing transcutaneous diagnostic catheterization and angiography were studied.
  • Active clotting time (ACT) was measured at baseline, 2, and 60 minutes after a 50 IU/kg heparin loading dose.
  • Statistical analysis included Wilcoxon, Mann-Whitney, and Pearson tests (SPSS 16), with P < 0.05 considered significant.

Main Results:

  • No significant difference in ACT was observed between cyanotic and non-cyanotic groups at 2 or 60 minutes post-heparin.
  • A more pronounced decrease in ACT was noted in older children at the 60-minute mark.

Conclusions:

  • Cyanosis does not influence ACT measurements following heparin treatment.
  • Heparin efficacy, indicated by ACT values, decreases more significantly with increasing patient age after 60 minutes.
Abstract

Keywords:
Active Clotting TimeCatheterizationCyanosisHeparin

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