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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Brain Abscess l: Introduction01:26

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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
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Increased Intracranial Pressure l: Introduction01:14

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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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Invasive cranial mycosis our experiences.

Tapas Kumbhkar1, Shaifali Bansal, Sushil Jindal

  • 1Department of General Medicine, Peoples College of Medical Sciences and Research Centre, Bhanpur, Bhopal, Madhya Pradesh, India.

Indian Journal of Endocrinology and Metabolism
|November 20, 2013
PubMed
Summary
This summary is machine-generated.

Fungal cranial infections in immunocompromised and diabetic patients, often caused by Aspergillus and Mucor, lead to severe tissue destruction and high mortality. This study reviews six cases of these challenging infections.

Keywords:
Immunocompromised stateMycosiscomplete ophthalmoplegidiabetes

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurosurgery

Background:

  • Fungal infections pose a significant threat to immunocompromised and diabetic individuals.
  • Cranial infections by fungi like Aspergillus and Mucor are particularly dangerous.

Observation:

  • These fungi invade and destroy adjacent cranial structures, including sinuses, orbit, and ethmoid regions.
  • Patients often present with severe symptoms due to extensive tissue damage.
  • High mortality and morbidity rates are observed despite aggressive multimodal treatment.

Findings:

  • The study details the clinical experience with six cases of invasive fungal cranial infections.
  • Common pathogens identified were Aspergillus and Mucor species.
  • Treatment involved combined surgical intervention, antifungal therapy, and diabetes management.

Implications:

  • Early diagnosis and aggressive treatment are crucial for managing invasive fungal sinusitis.
  • Understanding the patterns of tissue invasion is key to surgical planning.
  • Further research is needed to improve outcomes for these devastating infections.