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Genetics and heart failure: a concise guide for the clinician.
Cecile Skrzynia, Jonathan S Berg, Monte S Willis
1UNC Division of Cardiology, 160 Dental Circle, CB 7075, Chapel Hill, NC 27599-7075, USA. bcjensen@med.unc.edu.
Current Cardiology Reviews
|November 21, 2013
Summary
Genetic factors play a role in heart failure, particularly in familial dilated cardiomyopathy. Advances in genetic testing aid diagnosis and management of heritable heart conditions.
Area of Science:
- Cardiology
- Genetics
- Molecular Biology
Background:
- Heart failure pathogenesis involves complex genetic and environmental interactions.
- Genetic factors influence susceptibility, progression, and treatment response in heart failure.
- Familial dilated cardiomyopathy has a significant genetic basis, often overlooked previously.
Purpose of the Study:
- To review the genetic underpinnings of heart failure.
- To highlight the role of genetics in dilated cardiomyopathy.
- To discuss advancements in diagnosing and managing heritable heart failure.
Main Methods:
- Literature review of genetic studies in heart failure.
- Analysis of genetic polymorphisms in cardiovascular systems.
- Examination of genetic mutations in familial dilated cardiomyopathy.
Main Results:
- Genetic variants in adrenergic and renin-angiotensin-aldosterone systems show modest risk for heart failure.
- Up to 50% of dilated cardiomyopathy cases may stem from heritable mutations.
- Autosomal dominant inheritance patterns are common in familial dilated cardiomyopathy.
Conclusions:
- Genetic testing advancements improve diagnosis of familial dilated cardiomyopathy.
- Specialized genetic counseling is crucial for patients with heritable heart failure.
- Online resources support clinicians in managing genetic heart conditions.
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