Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Protists IV01:27

Diversity of Protists IV

2.1K
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
2.1K
Diversity of Protists II01:27

Diversity of Protists II

2.3K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
2.3K
Diversity of Protists III01:27

Diversity of Protists III

2.1K
Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Red pericarp trait, common to weedy rice, contributes to freezing tolerance of seeds and their ability to overwinter in soil.

AoB PLANTS·2026
Same author

Development of a high-efficiency induction system for embryonic oral epithelium from human pluripotent stem cells.

Stem cell reports·2026
Same author

Effects of Porphyromonas gingivalis-derived lipopolysaccharide on the barrier function of cultured junctional epithelial cells.

Journal of oral biosciences·2026
Same author

Inflammatory characteristics induced by cellular senescence in the junctional epithelium of aged mice.

Journal of oral biosciences·2026
Same author

Onnamides A and B Suppress Hepatitis B Virus Transcription by Inhibiting Viral Promoter Activity.

Marine drugs·2026
Same author

Leucascine, a β-alkylpyridine from the Okinawan sponge <i>Leucascus protogenes</i>.

Natural product research·2026

Related Experiment Video

Updated: May 5, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
16:03

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

Published on: January 11, 2015

8.6K

Two new compounds from an Indonesian sponge Dysidea sp.

Agus Trianto1, Nicole J de Voodg, Junichi Tanaka

  • 1a Department of Marine Sciences , Diponegoro University , Tembalang-Semarang Central Java Indonesia 50275 .

Journal of Asian Natural Products Research
|November 21, 2013
PubMed
Summary

Researchers discovered two novel compounds, biaketide and debromoantazirine, from an Indonesian marine sponge extract. Both compounds exhibited moderate cytotoxicity against NBT-T2 cells, indicating potential for further drug discovery.

More Related Videos

VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders
08:57

VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders

Published on: August 3, 2016

10.5K
A Method for Extracting Pigments from Squid Doryteuthis pealeii
11:03

A Method for Extracting Pigments from Squid Doryteuthis pealeii

Published on: November 9, 2016

9.1K

Related Experiment Videos

Last Updated: May 5, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
16:03

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

Published on: January 11, 2015

8.6K
VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders
08:57

VacuSIP, an Improved InEx Method for In Situ Measurement of Particulate and Dissolved Compounds Processed by Active Suspension Feeders

Published on: August 3, 2016

10.5K
A Method for Extracting Pigments from Squid Doryteuthis pealeii
11:03

A Method for Extracting Pigments from Squid Doryteuthis pealeii

Published on: November 9, 2016

9.1K

Area of Science:

  • Marine Biology
  • Natural Product Chemistry
  • Pharmacology

Background:

  • Marine invertebrates are a rich source of novel bioactive compounds.
  • Bioprospecting of Indonesian marine sponges is ongoing.
  • Previous research on Dysidea sp. has yielded various chemical entities.

Purpose of the Study:

  • To isolate and characterize new compounds from the Indonesian marine sponge Dysidea sp.
  • To evaluate the cytotoxic activity of the isolated compounds.
  • To contribute to the understanding of marine natural products from the Indo-Pacific region.

Main Methods:

  • Bioprospecting of marine sponge Dysidea sp. from Biak, West Papua.
  • Extraction and chromatographic separation of sponge metabolites.
  • Structure elucidation using spectroscopic analyses (NMR, MS).
  • Cytotoxicity assays against NBT-T2 cell line.

Main Results:

  • Two new compounds, biaketide (1) and debromoantazirine (2), were identified.
  • Four known compounds (3-6) were also isolated and characterized.
  • Biaketide (1) showed a moderate cytotoxicity with an IC50 of 8.3 μg/mL.
  • Debromoantazirine (2) displayed moderate cytotoxicity with an IC50 of 4.7 μg/mL against NBT-T2 cells.

Conclusions:

  • The marine sponge Dysidea sp. harbors novel cytotoxic compounds.
  • Biaketide and debromoantazirine represent potential leads for anticancer drug development.
  • Further investigation into the mechanism of action and structure-activity relationships is warranted.