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Updated: May 5, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Two new compounds from an Indonesian sponge Dysidea sp
Agus Trianto1, Nicole J de Voodg, Junichi Tanaka
1a Department of Marine Sciences , Diponegoro University , Tembalang-Semarang Central Java Indonesia 50275 .
Abstract:
On our joint bioprospecting research on Indonesian marine invertebrates, we found moderate cytotoxicity on an extract of the sponge Dysidea sp. collected at Biak, West Papua. Separation of the extract provided two new compounds, biaketide (1) and debromoantazirine (2), along with four known molecules 3-6. The new structures were elucidated by spectroscopic analyses and by comparison with those reported. Compounds 1 and 2 showed moderate cytotoxicity against NBT-T2 cells with IC50 values of 8.3 and 4.7 μg ml(- 1), respectively.
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