Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epistaxis01:30

Epistaxis

864
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
864
Suctioning the Nasopharyngeal Airway01:29

Suctioning the Nasopharyngeal Airway

6.6K
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
6.6K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.4K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical Assessments of a Novel Peel and Place Extended-Wear Negative-Pressure Wound Therapy Dressing for up to 35 Days in a Porcine Model.

Advances in wound care·2024
Same author

Preclinical assessment of novel longer-duration wear negative pressure wound therapy dressing in a porcine model.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2023
Same author

Mechanoporation is a potential indicator of tissue strain and subsequent degeneration following experimental traumatic brain injury.

Clinical biomechanics (Bristol, Avon)·2018
Same author

Planimetric Post-hoc Analysis of Women With Onychomycosis from Tavaborole 5% Phase III Studies: Evidence of Greater Improvements in Patients With >50% Baseline Infection.

Journal of drugs in dermatology : JDD·2018
Same author

Abstract 137: negative pressure wound therapy with instillation accelerates the granulation response with gene expression variations while maintaining comparable tissue quality compared to continuous and non-continuous negative pressure wound therapy in a porcine model.

Plastic and reconstructive surgery·2015
Same author

The effects of normal saline instillation in conjunction with negative pressure wound therapy on wound healing in a porcine model.

Wounds : a compendium of clinical research and practice·2015

Related Experiment Video

Updated: May 5, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
06:45

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

994

Science supporting negative pressure wound therapy with instillation.

Anthony M Rycerz1, Diwi Allen, M Christian Lessing

  • 1Kinetic Concepts, Inc., San Antonio, TX, USA.

International Wound Journal
|November 21, 2013
PubMed
Summary
This summary is machine-generated.

Negative pressure wound therapy with instillation (NPWTi) ensures uniform wound solution distribution and reduces bacterial aerosolization. This advanced therapy promotes granulation tissue formation and effective wound cleansing.

Keywords:
Negative pressure wound therapyNegative pressure wound therapy with instillationPeriodic instillationReticulated open-cell foamWound cleansing

More Related Videos

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

2.4K
Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds
04:58

Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds

Published on: October 20, 2012

11.6K

Related Experiment Videos

Last Updated: May 5, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
06:45

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

994
Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

2.4K
Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds
04:58

Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds

Published on: October 20, 2012

11.6K

Area of Science:

  • Wound Healing and Regenerative Medicine
  • Biomedical Engineering
  • Infectious Disease Control

Background:

  • Negative pressure wound therapy (NPWT) is a standard treatment for complex wounds.
  • Current NPWT methods may have limitations in topical solution delivery and bacterial aerosolization.
  • A novel approach combining NPWT with topical solution instillation (NPWTi) has been developed.

Purpose of the Study:

  • To evaluate the efficacy of NPWTi in simulated wound models and in vivo studies.
  • To compare solution distribution and bacterial aerosolization between NPWTi and conventional methods.
  • To assess the impact of NPWTi on granulation tissue formation and wound cleansing.

Main Methods:

  • Simulated wound models were used to compare solution distribution with and without an instillation soak phase.
  • In vitro studies assessed bacterial particle aerosolization during wound cleansing.
  • Porcine models were used to evaluate granulation tissue formation and wound cleansing efficacy compared to NPWT and pulsed lavage.

Main Results:

  • The instillation soak phase in NPWTi ensured uniform solution distribution across simulated wound beds.
  • NPWTi significantly decreased bacterial particle aerosolization compared to low-pressure wound cleansers (P < 0.05).
  • NPWTi with saline instillation induced 43% more granulation tissue than NPWT alone (P < 0.05) and was as effective as pulsed lavage for wound cleansing.

Conclusions:

  • NPWTi offers improved topical solution delivery and reduced bacterial spread during wound cleansing.
  • This therapy enhances granulation tissue formation and provides effective wound cleansing.
  • NPWTi represents a promising advancement in wound management, integrating NPWT benefits with enhanced cleansing capabilities.