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Updated: May 5, 2026

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
Published on: March 8, 2017
Integrating actin dynamics, mechanotransduction and integrin activation: the multiple functions of actin binding
Corina Ciobanasu1, Bruno Faivre, Christophe Le Clainche
1Laboratoire d'Enzymologie et Biochimie Structurales CNRS, avenue de la terrasse, 91198 Gif-sur-Yvette, France.
Abstract:
Focal adhesions are clusters of integrin transmembrane receptors that mechanically couple the extracellular matrix to the actin cytoskeleton during cell migration. Focal adhesions sense and respond to variations in force transmission along a chain of protein-protein interactions linking successively actin filaments, actin binding proteins, integrins and the extracellular matrix to adapt cell-matrix adhesion to the composition and mechanical properties of the extracellular matrix. This review focuses on the molecular mechanisms by which actin binding proteins integrate actin dynamics, mechanotransduction and integrin activation to control force transmission in focal adhesions.
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