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Published on: August 18, 2014
Reorganization of sensory pathways after neonatal hemidecortication in rats
Oraphan Wanakhachornkrai1, Tatsuya Umeda2, Kaoru Isa2
1Department of Developmental Physiology, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences (NINS), Myodaiji, Okazaki, Japan; Physiology Unit, Department of Medical Sciences, Faculty of Sciences, Rangsit University, Pathumthani, Thailand; Inter-disciplinary Program of Physiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
Abstract:
We investigated ascending somatosensory pathways in neonatally hemidecorticated rats. Injection of an anterograde tracer, biotinylated dextran amine (BDA), into the contralesional dorsal root ganglions revealed ipsilateral projections to the dorsal column nuclei (DCN) in hemidecorticated rats as well as in normal rats. Injection of BDA into the DCN on the same side revealed that while most axons projected to the contralateral thalamus, some axons were detected in the ipsilateral thalamus in hemidecorticated rats while such projections were rarely detected in normal rats. The results suggest that aberrant ipsilateral projections of DCN neurons contralateral to the lesion developed after the hemidecortication.
