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Related Experiment Video

Updated: May 5, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

Hyperventilation during electroencephalography: safety and efficacy.

Nick Kane¹, Lesley Grocott², Ros Kandler³

¹The Grey Walter Department of Clinical Neurophysiology, Frenchay Hospital, Bristol BS16 1LE, United Kingdom.

|November 21, 2013

Summary

Hyperventilation (HV) during electroencephalography (EEG) is safe and effective for diagnosing epilepsy. It rarely causes adverse events but helps identify seizure disorders in many patients.

Keywords:

Adverse events Hyperventilation Interictal epileptiform discharges Seizures

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Last Updated: May 5, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

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Published on: January 13, 2018

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Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI

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Published on: March 19, 2021

Area of Science:

Neurology
Clinical Neurophysiology

Background:

Electroencephalography (EEG) is crucial for diagnosing seizure disorders.
Hyperventilation (HV) is a common activation technique used during EEG.

Purpose of the Study:

To evaluate the safety and efficacy of hyperventilation (HV) during EEG.
To assess adverse events, provoked seizures, and interictal epileptiform discharges associated with HV.

Main Methods:

Prospective multicentre National Service Evaluation.
Involved 3475 outpatients investigated for possible epileptic seizures.
Monitored adverse events, seizures, and interictal epileptiform discharges during HV.

Main Results:

Adverse events were rare, with no significant cerebrovascular, cardiovascular, or respiratory events.
HV provoked seizures in 2.2% of epilepsy suspects, with only one generalized tonic-clonic seizure.
Interictal epileptiform discharges increased in 12.2% of patients; 0.9% experienced psychogenic non-epileptic seizures.

Conclusions:

HV is a safe activation technique in diagnostic EEG for selected patients.
HV aids in diagnosing and classifying seizure disorders, including non-epileptic attacks.
The benefits of HV in EEG outweigh the risks, informing consent processes.