Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

M-current in human neocortical neurones.

J V Halliwell

    Neuroscience Letters
    |June 6, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified the M-current (IM), a non-inactivating potassium current, in human neocortical neurons. This M-current is suppressed by muscarine, suggesting it

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Serotonin modulates glutamatergic transmission in the rat olfactory tubercle.

    The European journal of neuroscience·2010
    Same author

    ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells.

    Neuroscience letters·2008
    Same author

    Electrophysiological characterization of laminar synaptic inputs to the olfactory tubercle of the rat studied in vitro: modulation of glutamatergic transmission by cholinergic agents is pathway-specific.

    The European journal of neuroscience·2001
    Same author

    Evidence for enhancement of gap junctional coupling between rat island of Calleja granule cells in vitro by the activation of dopamine D3 receptors.

    The Journal of physiology·1998
    Same author

    Membrane properties of the granule cells of the islands of Calleja of the rat studied in vitro.

    The Journal of physiology·1995
    Same author

    Barium ions fail to support neurotransmission at a central synapse.

    Neuroscience letters·1994
    Same journal

    Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

    Neuroscience letters·2026
    Same journal

    Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

    Neuroscience letters·2026
    Same journal

    Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

    Neuroscience letters·2026
    Same journal

    Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

    Neuroscience letters·2026
    Same journal

    Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

    Neuroscience letters·2026
    Same journal

    Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

    Neuroscience letters·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Electrophysiology
    • Human Brain Research

    Background:

    • Human neocortical neurons possess complex electrical properties.
    • Understanding neuronal ion channel function is crucial for brain research.

    Purpose of the Study:

    • To investigate the presence and characteristics of ion currents in human neocortical neurons.
    • To identify specific currents, such as the M-current (IM), and their modulatory properties.

    Main Methods:

    • Intracellular recordings and voltage-clamp techniques were employed on human neocortical slices.
    • Experiments were conducted with and without calcium (Ca2+) flux blockers (Cd2+).
    • The effects of muscarine on neuronal currents were assessed.

    Main Results:

    Related Experiment Videos

    • A non-inactivating potassium (K+) current, the M-current (IM), was detected in over half of the studied human neocortical neurons.
    • This current activated at potentials positive to -60 mV and was insensitive to Ca2+ flux blockade.
    • Muscarine significantly suppressed the M-current (IM), confirming its identity and cholinergic modulation.

    Conclusions:

    • The M-current (IM) is present and functional in human neocortical neurons.
    • These findings validate the extrapolation of animal-derived data to human neuronal physiology.
    • The M-current (IM) represents a key target for cholinergic modulation in the human brain.