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Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule
Published on: May 9, 2025
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Developmental changes in renal tubular transport-an overview.
Jyothsna Gattineni1, Michel Baum2,3
1Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9061, USA.
Pediatric Nephrology (Berlin, Germany)
|November 21, 2013
Summary
Neonatal kidneys maintain fluid balance despite immature function. Postnatal development involves complex changes in transporters and signaling, not just increased abundance, enabling mature kidney function.
Area of Science:
- Nephrology
- Developmental Biology
- Physiology
Background:
- Adult kidneys regulate extracellular fluid volume and composition effectively.
- Neonatal kidneys have lower glomerular filtration rates and immature tubules.
- Despite immaturity, neonates maintain stable extracellular fluid homeostasis.
Purpose of the Study:
- To review neonatal kidney tubular function.
- To highlight differences between neonatal and adult tubular function.
- To discuss factors driving postnatal renal tubular development.
Main Methods:
- Review of existing literature on neonatal and adult renal physiology.
- Analysis of studies on renal transporter expression and function during development.
- Examination of signal transduction pathways in developing nephrons.
Main Results:
- Neonatal renal tubular development is complex, involving more than just increased transporter abundance.
- Isoform changes in transporters and altered signal transduction impact solute and water reabsorption.
- Significant differences exist in tubular transport capacity between neonates and adults.
Conclusions:
- Neonatal kidney function relies on intricate developmental processes.
- Understanding these maturational changes is crucial for comprehending renal development.
- Postnatal development involves sophisticated molecular and cellular adaptations in renal tubules.
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