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Testosterone concentrations in young healthy US versus Chinese men
L Xu1, S L Au Yeung, S Kavikondala
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China.
Summary
Young US men have higher total testosterone (TT) than Chinese men, but free (FT) and bioavailable testosterone (Bio T) levels are similar. These findings may explain disease pattern differences between Western and Asian populations.
Area of Science:
- Endocrinology
- Comparative physiology
- Population health
Background:
- Previous studies on ethnic differences in testosterone levels yielded inconsistent results.
- Age and socioeconomic factors may confound existing research on testosterone concentrations.
Purpose of the Study:
- To investigate differences in total testosterone (TT), free testosterone (FT), and bioavailable testosterone (Bio T) between young men from the US and Hong Kong (HK).
Main Methods:
- Cross-sectional analysis of 365 US men (NHANES III) and 299 Chinese men (university students).
- Participants were aged 18–29 years.
- Measured TT, calculated Bio T, and FT concentrations.
Main Results:
- Testosterone levels (TT, FT, Bio T) peaked in both groups between 20-24 years old.
- US men aged 18-24 had higher TT than Chinese men after age adjustment.
- No significant differences in FT or Bio T were observed between US and Chinese men in this age group.
Conclusions:
- Young, healthy Chinese men exhibit lower total testosterone (TT) concentrations compared to their US counterparts.
- Differences in TT, but not FT or Bio T, may contribute to varying disease prevalence observed between Western and Asian populations.
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