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Drug Distribution: Tissue Binding

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...

Tissue-Drug Binding: Localization of Drugs and its Significance

Tissue-Drug Binding: Localization of Drugs and its Significance

Body tissues, comprising approximately 40% of the body weight, are crucial in drug distribution and localization. These tissues can serve as drug storage sites, competing with plasma binding sites for drug molecules.
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...

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Related Experiment Video

Updated: May 5, 2026

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

Tissue distribution of some elements in rats.

G Leblondel¹, Y Mauras, P Allain

¹Laboratoire de Pharmacologie, C.H.U., 49040, Angers, France.

Biological Trace Element Research

|November 21, 2013

Summary

This summary is machine-generated.

This study measured 14 elements in rat tissues and plasma. Results reveal distinct element concentration sequences and distribution homogeneity across various organs.

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Area of Science:

Toxicology
Biochemistry
Analytical Chemistry

Background:

Understanding elemental concentrations in biological tissues is crucial for toxicology and physiology.
Rat models are frequently used to study element distribution and metabolism.
Previous studies have focused on specific elements, but a comprehensive multielemental analysis across diverse tissues is needed.

Purpose of the Study:

To quantify the concentrations of 14 elements in various rat tissues and plasma.
To determine the tissue-to-plasma concentration ratios for assessing element distribution.
To evaluate the homogeneity of elemental distribution across different organs.

Main Methods:

Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) was employed for multielemental analysis.
Whole blood, plasma, brain, heart, skeletal muscle, liver, kidney, spleen, thymus, and bone were analyzed.
Tissue-to-plasma concentration ratios were calculated to assess distribution patterns.

Main Results:

Distinct concentration sequences were observed for elements across tissues, with Rb>P≥K>(Fe)>Zn≥Mg>Cu>S>(Sr≥Ca>Na) being a likely order.
Element distribution homogeneity varied, with (Fe)
Significant variations in elemental concentrations and distribution were found among different organs.

Conclusions:

The study provides a comprehensive dataset on the distribution of 14 elements in rat tissues.
ICP-OES is a suitable method for multielemental analysis in biological samples.
Findings contribute to a better understanding of element homeostasis and toxicokinetics in mammals.