Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.1K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.1K
Computed Tomography01:10

Computed Tomography

7.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.6K
Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

861
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
861
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

10.8K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophages in protective immunity to Hymenolepis nana in mice.

Immunology and cell biology·1992
Same author

Establishment of a folliculo-stellate-like cell line from a murine thyrotropic pituitary tumor.

Endocrinology·1992
Same author

The effects of sodium chloride, miso or ethanol on development of intestinal metaplasia after X-irradiation of the rat glandular stomach.

Japanese journal of cancer research : Gann·1992
Same author

Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons.

Journal of neurobiology·1992
Same author

The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum.

The EMBO journal·1992
Same author

Chemotactic factor in the pregnant rabbit uterine cervix.

American journal of obstetrics and gynecology·1992

Related Experiment Video

Updated: May 5, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.7K

Proton computed tomography applied to small biomedical samples.

A Ito1, H Koyama-Ito

  • 1Cyclotron Lab., Institute of Medical Science, Tokyo Univ., 4-6-1 Minato-ku, 108, Tokyo, Japan.

Biological Trace Element Research
|November 21, 2013
PubMed
Summary
This summary is machine-generated.

Proton computed tomography (CT) offers superior soft tissue analysis compared to X-ray CT. This new system achieves high-resolution imaging for biomedical samples, aiding in cataract research.

More Related Videos

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
08:46

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

Published on: April 13, 2016

9.6K
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

13.2K

Related Experiment Videos

Last Updated: May 5, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.7K
Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
08:46

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

Published on: April 13, 2016

9.6K
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

13.2K

Area of Science:

  • Medical Imaging
  • Biophysics
  • Particle Physics

Background:

  • Conventional X-ray CT has limitations in soft tissue density resolution.
  • High-energy proton beams offer potential for enhanced density discrimination.
  • Biomedical imaging requires high resolution for detailed analysis of small structures.

Purpose of the Study:

  • To develop and evaluate a first-generation proton CT system for high-resolution density analysis of small biomedical samples.
  • To assess the system's capability in distinguishing subtle density variations in biological tissues.
  • To apply the proton CT technique to study changes in lens density associated with cataract development.

Main Methods:

  • A 25-MeV proton beam was used with a semi-micro beam width (0.06 mm FWHM).
  • Specimens were scanned in a water bath, and residual proton energy was measured using a solid-state detector.
  • Filtered back projection with the Shepp-Logan function reconstructed density images from projection data.

Main Results:

  • Achieved spatial resolution of 0.1 mm.
  • Obtained density resolution of 0.1%.
  • Demonstrated application to small animal eyes, analyzing lens density changes in cataracts.

Conclusions:

  • The developed proton CT system provides superior spatial and density resolution for small biomedical samples compared to X-ray CT.
  • This technique is promising for detailed studies of tissue density, particularly in ophthalmology for cataract research.
  • Proton CT represents a significant advancement in high-resolution biomedical imaging.