Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

12.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.5K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

16.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.0K
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

118
Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect...
118
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

82
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
82
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

50
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
50
Inflammation: Introduction01:28

Inflammation: Introduction

84
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
84

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking metabolism and metastasis: elevated α-hydroxybutyric acid in oral squamous cell carcinoma patients with lymph node metastasis.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

The metabolic profiles of cancer stem cells.

Stem cell research & therapy·2026
Same author

Heterogeneity of glucose metabolism and uptake identifies distinct cancer cell and cancer stem cell phenotypes.

Cellular & molecular biology letters·2026
Same author

Reduced structural rigidity of MDMX protein enhances binding to TP53 mRNA.

Bioscience reports·2025
Same author

CDK11 inhibition induces cytoplasmic p21<sup>WAF1</sup> splice variant by p53 stabilisation and SF3B1 inactivation.

Molecular oncology·2025
Same author

A Unique Plasma Protein Signature Characterizes Squamous Cell Carcinoma of the Oral Tongue in Young Adults.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2025

Related Experiment Video

Updated: May 5, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.4K

Responses to ionizing radiation mediated by inflammatory mechanisms.

Debayan Mukherjee1, Philip J Coates, Sally A Lorimore

  • 1Centre for Oncology and Molecular Medicine, University of Dundee Medical School, Dundee, DD1 9SY, UK.

The Journal of Pathology
|November 21, 2013
PubMed
Summary

Radiation exposure causes biological effects beyond immediate DNA damage, involving intercellular signaling and inflammation. These delayed and distant effects, including genomic instability and bystander effects, impact tissue responses and disease progression.

Keywords:
inflammationmacrophagesnon-targeted effectsradiationtissue microenvironment

More Related Videos

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.6K
Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

10.6K

Related Experiment Videos

Last Updated: May 5, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.4K
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.6K
Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

10.6K

Area of Science:

  • Radiation biology
  • Cellular signaling
  • Inflammation research

Background:

  • Traditionally, radiation effects were solely attributed to direct DNA damage or cell death.
  • Observations of abscopal effects and plasma factors challenged this dogma.
  • Recent research highlights radiation-induced genomic instability and bystander effects.

Purpose of the Study:

  • To explore mechanisms of radiation-induced biological effects beyond direct cellular damage.
  • To investigate the role of intercellular signaling and inflammatory responses in radiation pathology.
  • To understand the implications of these findings for radiation-related diseases and therapies.

Main Methods:

  • Review of historical and recent literature on radiation biology.
  • Analysis of studies on abscopal effects, plasma factors, genomic instability, and bystander effects.
  • Consideration of evidence linking radiation effects to inflammatory responses.

Main Results:

  • Radiation effects extend beyond directly irradiated cells, involving intercellular communication.
  • An ongoing inflammatory response to radiation injury can cause damage displaced in time and space.
  • Non-steroidal anti-inflammatory drugs show potential in reducing radiation-induced damage in vivo.
  • Radiation's role may extend to tumor promotion and progression, not just initiation.

Conclusions:

  • Radiation biological consequences are mediated by intercellular signaling and inflammatory processes.
  • These findings necessitate a broader understanding of radiation pathology and therapeutic strategies.
  • Radiation effects are dynamic and can influence disease progression.