[Clinical experiences with systemic high-dosage short-term fibrinolysis in acute myocardial infarct]

In 50 patients with acute myocardial infarction the systemic highly dosed short-term lysis with streptokinase took place within the 6-hour limit. 27 patients showed a normalisation of the ST-distance still during the treatment, 16 of whom did not develop any signs of necrosis in the ECG also in the further course. Pre-existing disturbances of rhythm receded under the infusion of streptokinase in 8 of 9 patients. In 11 patients arrhythmias appeared under the lysis, which could be brought under control in intensive-medical conditions. 4 patients died, 1 patient suffered a re-infarction. The results of the treatment were better, when the fibrinolysis began within 3 hours after the acute onset. Severe side effects did not appear.