Curative diet supplementation with a melon superoxide dismutase reduces adipose tissue in obese hamsters by improving
Julie Carillon1, Lucie Knabe, Anne Montalban
1Nutrition & Métabolisme, UMR 204 NutriPass - Prévention des Malnutritions et des Pathologies Associées, Université Montpellier Sud de France, Montpellier, France; Bionov Sarl, Avignon, France.
Scope:
Obesity-related metabolic syndrome is often associated with a decrease of insulin sensitivity, inducing several modifications. However, dietary antioxidants could prevent insulin resistance. We have previously shown the preventive effects of a melon superoxide dismutase (SOD) in obese hamsters. However, its antioxidant effects have never been studied on adipose tissue.
Methods And Results:
We evaluated the effects of a 1-month curative supplementation with SODB on the adipose tissue of obese hamsters. Animals received either a standard diet or a cafeteria diet for 15 wk. Cafeteria diet induced obesity and related disorders, including insulin resistance and oxidative stress, in the abdominal adipose tissue. After SODB supplementation, the adipose tissue weight was decreased, probably by activating adipocytes lipolysis and thus reducing their size. SODB treatment also resulted in abdominal adipose tissue fibrosis reduction. Finally, SODB administration increased the expression of endogenous antioxidant enzymes and thus reduced oxidative stress and insulin resistance. The improvement of insulin sensitivity observed after SODB treatment could explain adipocyte lipolysis activation and fibrosis reduction.
Conclusion:
These findings demonstrate that a dietary SOD supplementation could be a useful strategy against obesity-related modifications in adipose tissue.
Insights
Dietary melon superoxide dismutase (SOD) supplementation reduced adipose tissue weight and improved insulin sensitivity in obese hamsters. This antioxidant strategy combats obesity-related metabolic changes.
Area of Science:
- Metabolic Syndrome Research
- Adipose Tissue Biology
- Oxidative Stress Studies
Background:
- Obesity-related metabolic syndrome frequently decreases insulin sensitivity.
- Dietary antioxidants show potential in preventing insulin resistance.
- Previous studies indicated melon superoxide dismutase (SOD) has preventive effects in obese hamsters.
Purpose of the Study:
- To investigate the antioxidant effects of melon superoxide dismutase (SOD) on adipose tissue.
- To evaluate the impact of SOD supplementation on obesity-induced metabolic changes in adipose tissue.
Main Methods:
- Obese hamsters were supplemented with SOD for one month.
- Animals were fed either a standard or cafeteria diet to induce obesity and related disorders.
- Effects on abdominal adipose tissue, including weight, lipolysis, fibrosis, oxidative stress, and insulin resistance, were assessed.
Main Results:
- SOD supplementation decreased adipose tissue weight, likely via lipolysis activation.
- Treatment reduced abdominal adipose tissue fibrosis and oxidative stress.
- SOD administration enhanced endogenous antioxidant enzyme expression, improving insulin sensitivity.
Conclusions:
- Dietary SOD supplementation effectively reduced obesity-related modifications in adipose tissue.
- SOD demonstrates potential as a therapeutic strategy for managing metabolic dysfunction associated with obesity.
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