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Glomerular filtration rate is altered in children with sickle cell disease: a comparison between Hb SS and Hb SC

Rafael Pereira de Paula1, Alana Ferreira Nascimento, Sandra Mara Bispo Sousa

  • 1Universidade Estadual do Sudoeste da Bahia - UESB, Jequié, BA, Brazil.

Revista Brasileira De Hematologia E Hemoterapia
|November 21, 2013
PubMed

Insights

Glomerular hyperfiltration, a precursor to renal failure in sickle cell disease, is present in children. This condition is more pronounced in homozygotic (SS) sickle cell disease patients than heterozygotic (SC) patients.

Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Sickle Cell Disease Research

Background:

  • Renal failure is a common complication in older adults with sickle cell disease (SCD).
  • Subclinical glomerular hyperfiltration often precedes renal failure in SCD.
  • Limited data exists on renal function in children with SCD, particularly comparing different genotypes.

Purpose of the Study:

  • To investigate and compare the glomerular filtration rate (GFR) in children with sickle cell disease.
  • To differentiate renal function between heterozygotic (SC) and homozygotic (SS) pediatric SCD patients.

Main Methods:

  • Evaluated the GFR in 11 children diagnosed with sickle cell disease.
  • Included 7 homozygotic (SS) and 4 heterozygotic (SC) patients, with a mean age of 11 years (±5 years).
  • Employed standard laboratory techniques for GFR assessment and descriptive analysis for results.

Main Results:

  • Glomerular hyperfiltration was observed in pediatric patients with sickle cell disease.
  • The degree of glomerular hyperfiltration was notably higher in homozygotic (SS) children compared to heterozygotic (SC) children.

Conclusions:

  • Findings indicate the presence of glomerular hyperfiltration in children with sickle cell disease.
  • Highlights the need for regular renal function monitoring in pediatric SCD patients.
  • Emphasizes increased vigilance for homozygotic (SS) patients due to higher risk.
Abstract

Keywords:
Anemia, sickle cell/complicationsChildGlomerular filtration rateHemoglobin SC diseaseHumansKidney glomerulus

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