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Related Experiment Video

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Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Lentinus edodes promotes fat removal in hypercholesterolemic mice.

Hyun Yang¹, Inho Hwang, Sun Kim

¹Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.

Experimental and Therapeutic Medicine

|November 21, 2013

Summary

Shiitake mushroom (Lentinus edodes) and its component eritadenine effectively lower high cholesterol and triglycerides in mice fed a high-fat diet. This suggests L. edodes regulates lipid metabolism by influencing liver CYP7A1 expression and reducing plaque formation.

Keywords:

CYP7A1 Lentinus edodes eritadenine hypercholesterolemia

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Area of Science:

Nutritional Science
Pharmacology
Biochemistry

Background:

Lentinus edodes (shiitake mushroom) is a traditional Asian medicine.
Eritadenine, a component of L. edodes, is known to reduce cholesterol levels.
Hepatic phospholipid metabolism is implicated in the hypocholesterolemic action of eritadenine.

Purpose of the Study:

To investigate the effects of L. edodes on hypercholesterolemia in a mouse model.
To determine the impact of L. edodes and eritadenine on lipid profiles and liver gene expression.
To assess the potential of L. edodes in ameliorating diet-induced hypercholesterolemia.

Main Methods:

Hypercholesterolemia was induced in mice using a high-fat diet (HFD).
Mice were treated with varying doses of L. edodes (5%, 10%, 20%) or eritadenine (10 mg/kg BW) for 4 weeks.
Serum lipid levels (Total Cholesterol, LDL, TG, HDL), liver lipid accumulation, atherosclerotic plaque formation, and CYP7A1 mRNA expression were analyzed.

Main Results:

HFD significantly increased serum Total Cholesterol, LDL, and TG levels, while HDL remained unchanged.
L. edodes administration dose-dependently reduced serum T-CHO, LDL, and TG levels.
Eritadenine and L. edodes treatments increased CYP7A1 mRNA expression, reduced liver lipid accumulation, and suppressed atherosclerotic plaque formation.

Conclusions:

High-fat diet consumption may inhibit hepatic CYP7A1 expression, leading to elevated serum lipid levels.
L. edodes demonstrates potential in regulating lipid metabolism and ameliorating hypercholesterolemia in mice.
The hypocholesterolemic effects of L. edodes are likely mediated through the regulation of CYP7A1 expression in the liver.