Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic histamine release from isolated human basophils during specific immunotherapy.

S Chyrek-Borowska, B Kuczewska, A Rogalewska

    Agents and Actions
    |April 1, 1986
    PubMed
    Summary

    Short-term immunotherapy with Pollinex significantly reduced histamine release from basophils in grass pollen-allergic patients. This suggests hyposensitization effectively modulates allergic responses by decreasing histamine release.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nitro- and oxy-PAHs in grassland soils from decade-long sampling in central Europe.

    Environmental geochemistry and health·2021
    Same author

    Spatial and temporal distribution of the currently-used and recently-banned pesticides in arable soils of the Czech Republic.

    Chemosphere·2020
    Same author

    Laboratory versus field soil aging: Impact on DDE bioavailability and sorption.

    Chemosphere·2017
    Same author

    Bacterial protein toxins P. Falmagne, J.E. Alouf, F.J. Fehrenbach, J. Jeljaszewicz, M. Thelestam (Eds.) : Zentralblatt für Bakteriologie und Hygiene, Supplement Vol. 15 Gustav Fischer Verlag, Stuttgart-New York 1986 398 pages, 93 figures, 64 tables.

    Folia microbiologica·2016
    Same author

    Association between severe disease course and nephritis with Q222R polymorphism in DNAse I gene among lupus patients: An Argentine multicenter study.

    Acta reumatologica portuguesa·2016
    Same author

    Assessment of the biological and chemical availability of the freshly spiked and aged DDE in soil.

    Environmental pollution (Barking, Essex : 1987)·2016

    Area of Science:

    • Immunology
    • Allergology
    • Cellular Biology

    Background:

    • Atopic patients exhibit heightened histamine release from basophils upon exposure to allergens.
    • Grass pollen allergy is a common condition characterized by allergic rhinitis and other symptoms.

    Purpose of the Study:

    • To evaluate the effect of short-term immunotherapy with Pollinex on histamine release from basophils.
    • To assess changes in anti-Immunoglobulin E (IgE) and antigen-induced histamine release after hyposensitization.

    Main Methods:

    • Basophils were isolated from 20 atopic patients sensitive to grass pollen.
    • Histamine release was measured before and after a short-term immunotherapy course with Pollinex.

    Main Results:

    Related Experiment Videos

  • A significant decrease in anti-IgE-induced histamine release was observed post-immunotherapy.
  • Specific antigen-induced histamine release from basophils also showed a significant reduction after hyposensitization.

    • Conclusions:

    • Short-term immunotherapy with Pollinex effectively reduces allergic mediator release in grass pollen-sensitive atopic individuals.
    • Hyposensitization appears to modulate basophil reactivity, offering a potential therapeutic strategy for allergic diseases.