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Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children

Jaroslav Kraus1, Eva Nártová, Emil Pavlík

  • 1Department of Otorhinolaryngology, Hospital of Rudolf & Stefanie Benešov.

Acta Oto-Laryngologica
|November 22, 2013
PubMed

Insights

Helicobacter pylori (HP) was found in 98% of pediatric adenotonsillar tissue samples. This suggests the pharynx may serve as a reservoir for HP, potentially impacting upper respiratory conditions.

Area of Science:

  • Microbiology
  • Pediatric Otolaryngology
  • Infectious Diseases

Background:

  • Helicobacter pylori (HP) is a significant human pathogen primarily associated with gastroduodenal diseases.
  • The potential for extragastric reservoirs of HP remains an area of investigation.
  • Understanding HP reservoirs is crucial for developing effective eradication and prevention strategies.

Purpose of the Study:

  • To investigate the presence and genotypes of Helicobacter pylori (HP) in adenotonsillar tissues of pediatric patients.
  • To evaluate the pharynx as a potential extragastric reservoir for HP.
  • To analyze the distribution of CagA and VacA genotypes in HP strains found in these tissues.

Main Methods:

  • A prospective study involving 37 pediatric patients undergoing adenoidectomy and/or tonsillectomy.
  • Collection and analysis of 49 adenotonsillar tissue specimens.
  • Real-time PCR was employed to detect HP and determine CagA and VacA genotypes.

Main Results:

  • Helicobacter pylori (HP) was detected in 98% (48 out of 49) of the analyzed adenotonsillar samples.
  • The VacAs1bm2 genotype was predominant in adenoid tissues, with broader distribution in tonsillar tissues.
  • CagA-positive (Cag+) HP strains constituted 21% of the total samples.

Conclusions:

  • The high prevalence of HP in adenotonsillar tissue supports the hypothesis of the pharynx as an extragastric reservoir for HP.
  • The findings suggest a potential role for HP in the pathophysiology of upper respiratory tract diseases in children.
  • Further research is warranted to elucidate the precise role of HP in these conditions.
Abstract

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