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Updated: May 5, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

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The relationship of aeroallergen sensitization phenotypes to asthma control in primarily Hispanic asthmatic children

T Morphew1, Kenny Y C Kwong, B Yang

  • 1Morphew Consulting, LLC , Manhattan Beach, CA , USA .

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|November 22, 2013
PubMed

Insights

Aeroallergen sensitization phenotypes can predict asthma control in children. Pollen sensitization may worsen asthma control in intermittent cases, while dander sensitization may protect persistent cases.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Environmental Health

Background:

  • Asthma affects millions of children globally.
  • Aeroallergen sensitization is a known risk factor for asthma development and exacerbations.
  • Predicting asthma control is crucial for effective management.

Purpose of the Study:

  • To investigate if aeroallergen sensitization phenotypes predict the maintenance of well-controlled asthma in children.
  • To explore the differential impact of indoor and outdoor aeroallergen sensitization on asthma control based on severity.

Main Methods:

  • Retrospective analysis of 1627 asthmatic children (age 2-18) from the CHOC Children's Breathmobile™ program.
  • Skin testing to indoor and outdoor aeroallergens.
  • Asthma severity and control assessed using NHLBI EPR-3 Guidelines criteria.

Main Results:

  • Children with persistent asthma showed higher sensitization rates to all aeroallergens compared to those with intermittent asthma.
  • Intermittent asthma patients sensitized to pollen were less likely to maintain asthma control.
  • Dander sensitization was protective for persistent asthma control but not for intermittent asthma.

Conclusions:

  • Aeroallergen sensitization assessment is recommended for all children with asthma, irrespective of baseline severity.
  • Understanding specific aeroallergen sensitization patterns can aid in personalized asthma management strategies.
Abstract

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