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HLA-B50 polymorphism in the Saudi population.

D Jawdat1, B Al-Hamad, M Al-Jumah

  • 1King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

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The HLA-B50 allele is prevalent in Saudi Arabia, with HLA-B*50:01:01 being the most common type found in healthy individuals. This study details its distribution in the Saudi population.

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Area of Science:

  • Immunogenetics
  • Human Leukocyte Antigen (HLA) complex research
  • Population genetics

Background:

  • The HLA-B50 serologic family is frequently observed in individuals of Arabic descent.
  • HLA-B50 represents the most prevalent Human Leukocyte Antigen (HLA) B allele within Saudi Arabia.
  • Understanding HLA allele distribution is crucial for transplantation and disease association studies.

Purpose of the Study:

  • To determine the specific distribution of Human Leukocyte Antigen (HLA)-B50 alleles among healthy Saudi Arabian individuals.
  • To identify the predominant HLA-B50 subtypes within this specific demographic group.

Main Methods:

  • Low-resolution Human Leukocyte Antigen (HLA) typing was performed on 162 healthy Saudi participants.
  • Sequence-based typing (SBT) was employed to analyze exons 2, 3, and 4 of the HLA-B locus.
  • HLA-B*50 alleles were analyzed using specialized SBT engine software.

Main Results:

  • The HLA-B*50:01:01 allele was identified in 161 out of 162 individuals, representing a frequency of 99.4%.
  • The HLA-B*50:09 allele was detected in a single individual, accounting for 0.6% of the cohort.
  • HLA-B*50:01:01 was confirmed as the most common HLA-B50 allele in the studied Saudi Arabian population.

Conclusions:

  • HLA-B*50:01:01 is the overwhelmingly dominant Human Leukocyte Antigen (HLA)-B50 allele in Saudi Arabia.
  • This finding provides essential data on HLA-B50 allele frequency in a key Middle Eastern population.
  • The high prevalence of HLA-B*50:01:01 has implications for HLA matching in clinical transplantation and disease susceptibility research within Saudi Arabia.