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Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

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Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
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Cushing Syndrome I: Introduction01:26

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Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
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Cerebral Edema ll: Pathophysiology01:22

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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
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Brain Abscess l: Introduction01:26

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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
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Increased Intracranial Pressure ll: Pathophysiology01:29

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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
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Related Experiment Video

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Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
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Cavernous sinus syndrome in a Holstein bull.

Sarah I Jacob1, Randi Drees, Marie E Pinkerton

  • 1Department of Medical Sciences, 2015 Linden Drive West, Madison, WI, 53706, USA.

Veterinary Ophthalmology
|November 22, 2013
PubMed
Summary

A Holstein bull developed exophthalmos and neurological deficits due to abscesses in the cavernous sinus. This case highlights the importance of considering cavernous sinus syndrome in cattle with similar clinical signs.

Keywords:
abscessationbullcavernous sinus syndromeexophthalmosopthalmoplegiaptosis

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Area of Science:

  • Veterinary Neurology
  • Ophthalmology
  • Bovine Medicine

Background:

  • A 13-month-old Holstein bull presented with right-sided exophthalmos and impaired ocular function.
  • Initial diagnostics, including radiographs, did not reveal underlying skull abnormalities or sinusitis.

Observation:

  • Ophthalmologic examination revealed a dilated, poorly responsive right pupil and absent ocular motility.
  • Despite a 14-day course of antibiotics and anti-inflammatories, the bull's condition did not improve.
  • The bull later developed recumbency, left-sided strabismus, and a fixed right pupil, leading to euthanasia.

Findings:

  • Postmortem MRI and examination identified bilateral abscesses obliterating the cavernous sinus region.
  • Associated findings included right mandibular abscessation, trigeminal neuritis, sinusitis, and otitis media.
  • Abscesses extended through the round foramina, impacting cranial nerves III, IV, V, and VI.

Implications:

  • Cavernous sinus syndrome should be considered in cattle presenting with exophthalmos and neuro-ophthalmologic deficits.
  • This syndrome involves multiple cranial nerves housed within the cavernous sinus.
  • Prompt recognition and diagnosis are crucial for managing complex neurological conditions in cattle.