Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

995
At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
995
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.4K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.4K
UV–Vis Spectroscopy of Conjugated Systems01:32

UV–Vis Spectroscopy of Conjugated Systems

5.9K
Organic compounds with conjugated double bonds show strong absorption features in the UV–visible region of the electromagnetic spectrum attributed to π → π* electronic excitations. Generally, a UV–vis absorption spectrum is recorded as a plot of absorbance vs wavelength. The wavelength of maximum absorbance, which manifests as a peak in the absorption spectrum, is denoted as λmax.
One of the factors influencing λmax is...
5.9K
2D NMR: Homonuclear Correlation Spectroscopy (COSY)01:06

2D NMR: Homonuclear Correlation Spectroscopy (COSY)

1.9K
Homonuclear correlation spectroscopy, or COSY, is a 2-dimensional NMR technique that provides information about coupled protons. Typically, the geminal and vicinal coupling are observed. For example, consider the COSY spectrum of ethyl acetate, where its 1D proton NMR spectrum is plotted along the vertical and horizontal axes with their corresponding chemical shift scale. Three spots on the diagonal corresponding to the three peaks in the 1D proton spectrum are called diagonal peaks. The COSY...
1.9K
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

807
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
807
IR and UV–Vis Spectroscopy of Aldehydes and Ketones01:29

IR and UV–Vis Spectroscopy of Aldehydes and Ketones

5.2K
Infrared spectroscopy, also known as vibrational spectroscopy, is mainly used to determine the types of bonds and functional groups in molecules. In aldehydes and ketones, the carbonyl (C=O) bond shows an absorption around 1710 cm-1. The C=O bond vibration of an aldehyde occurs at lower frequencies than that of a ketone. In addition to the C=O absorption in an aldehyde, the aldehydic C–H bond also gives two peaks in the 2700–2800 cm-1 range. This absorption, coupled with the...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperative Dinuclear Activation of a Formate Intermediate in the Hydrogenation of CO<sub>2</sub> to Methanol.

Molecules (Basel, Switzerland)·2026
Same author

Catalysis<sup>cubed</sup> Reloaded─Cyclopropanations inside Porphyrin-Based Supramolecular M<sub>8</sub>L<sub>6</sub> Aggregates.

Inorganic chemistry·2026
Same author

From [NHC─H]<sup>•</sup> to Persistent σ-Complex Radicals: Photoinduced Radical Chemistry of Imidazolium Salts.

Angewandte Chemie (International ed. in English)·2026
Same author

Effect of PFOA on the Secondary Structure and Hydration of Globular Proteins: A CD and 2D-IR Study.

The journal of physical chemistry. B·2026
Same author

Inorganic Cobalt Sandwich Complex [(η<sup>5</sup>-P<sub>5</sub>)Co(η<sup>3</sup>-P<sub>3</sub>)]<sup></sup>.

Journal of the American Chemical Society·2026
Same author

Redox Noninnocence in First-Row Transition Metal Complexes of a π-Extended β-Diketiminate.

Inorganic chemistry·2026

Related Experiment Video

Updated: May 5, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

2.8K

Exchanging conformations of a hydroformylation catalyst structurally characterized using two-dimensional vibrational

Matthijs R Panman1, Jannie Vos, Vladica Bocokić

  • 1Van 't Hoff Institute for Molecular Sciences, University of Amsterdam , Science Park 904, 1098 XH Amsterdam, The Netherlands.

Inorganic Chemistry
|November 22, 2013
PubMed
Summary

This study uses 2D vibrational spectroscopy to characterize the rapidly exchanging conformations of a hydroformylation catalyst. Findings reveal a unique bond angle deviation attributed to van der Waals forces.

More Related Videos

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures
08:49

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

Published on: December 1, 2023

2.2K
Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid
08:54

Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid

Published on: January 25, 2020

5.0K

Related Experiment Videos

Last Updated: May 5, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

2.8K
Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures
08:49

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

Published on: December 1, 2023

2.2K
Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid
08:54

Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid

Published on: January 25, 2020

5.0K

Area of Science:

  • Organometallic Chemistry
  • Spectroscopy
  • Computational Chemistry

Background:

  • Transition-metal catalysts exist in multiple, rapidly interconverting conformations in solution.
  • Characterizing these dynamic structures is challenging with conventional methods.
  • Understanding catalyst conformation is crucial for optimizing reactivity.

Purpose of the Study:

  • To determine specific bond angles in the two rapidly exchanging solution conformations of the (xantphos)Rh(CO)2H hydroformylation catalyst.
  • To demonstrate the applicability of 2D vibrational spectroscopy for characterizing dynamic catalyst structures.
  • To elucidate the structural and electronic factors influencing catalyst conformation.

Main Methods:

  • Two-dimensional vibrational spectroscopy was employed to probe the catalyst's structure in solution.
  • Density functional theory (DFT) calculations were performed to complement spectroscopic data.
  • Analysis focused on identifying specific bond angles and interactions within different catalyst conformers.

Main Results:

  • Specific bond angles in two rapidly exchanging conformations of (xantphos)Rh(CO)2H were successfully determined.
  • One conformation exhibited a significant deviation in the OC-Rh-CO angle from the ideal trigonal-bipyramidal geometry.
  • DFT calculations supported the spectroscopic findings and identified attractive van der Waals interactions.

Conclusions:

  • Two-dimensional vibrational spectroscopy is a powerful tool for characterizing dynamic catalytic systems.
  • Van der Waals interactions between the CO ligand and the xantphos ligand influence catalyst conformation.
  • The study provides new insights into the structural dynamics of hydroformylation catalysts.