GCN2, an old dog with new tricks
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Updated: May 5, 2026

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
Published on: May 24, 2016
1*Department of Cell Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway.
Abstract:
Gcn2 was first described in budding yeast as a serine/threonine protein kinase involved in the response to amino acid starvation and this is its best characterized role to date. Recent work has revealed new and exciting roles for Gcn2, which affect many aspects of cellular physiology in response to a number of stresses in addition to starvation. Furthermore, the Gcn2 pathway has been implicated in diseases such as cancer and Alzheimer's disease, and therefore elucidating the new roles of Gcn2 seems ever more important.
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