Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

2.7K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
2.7K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

2.9K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
2.9K
Meiosis II02:02

Meiosis II

32.7K
Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
32.7K
Forces Acting on Chromosomes02:11

Forces Acting on Chromosomes

3.1K
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis. 
Microtubules and motor proteins exert two types of forces on...
3.1K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

5.4K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.4K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

2.5K
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining.

Nature communications·2026
Same author

Glioblastoma invasion into different organoid hosts reveals cell-intrinsic and proliferative migratory programs.

iScience·2026
Same author

Author Correction: A PP1-PP2A phosphatase relay controls mitotic progression.

Nature·2026
Same author

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin.

Open biology·2023
Same author

A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Open biology·2021
Same author

Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling.

Journal of cell science·2019

Related Experiment Video

Updated: May 5, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

6.7K

Spatial control of mitotic commitment in fission yeast.

Iain M Hagan1, Agnes Grallert

  • 1*Cell Division Group, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, U.K.

Biochemical Society Transactions
|November 22, 2013
PubMed
Summary

Cell division timing is regulated by spatial signaling networks. Recent fission yeast studies reveal how spindle pole body organization links cell cycle commitment to environmental cues, ensuring timely mitosis.

More Related Videos

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

11.2K
Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

14.4K

Related Experiment Videos

Last Updated: May 5, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

6.7K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

11.2K
Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

14.4K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Mitotic commitment relies on the Cdk1-cyclin B complex, regulated by phosphorylation.
  • Wee1 kinases inhibit Cdk1, while Cdc25 phosphatases activate it, creating a rapid switch to mitosis.
  • The precise timing of this switch in response to environmental cues remains incompletely understood.

Purpose of the Study:

  • To investigate how spatial organization of signaling networks influences the timing of cell division.
  • To explore the role of the spindle pole body in coupling cell cycle commitment to environmental cues.

Main Methods:

  • Studies were conducted in fission yeast.
  • Analysis focused on the spatial organization of signaling networks, particularly events at the spindle pole body.

Main Results:

  • Spatial organization of signaling networks, especially at the spindle pole body, is crucial for regulating cell division timing.
  • This spatial organization ensures that the cell division timing is appropriately coupled to environmental cues.

Conclusions:

  • The spatial arrangement of molecular components within signaling pathways is a key determinant of cell cycle timing.
  • Understanding these spatial dynamics provides insight into how cells integrate environmental signals to initiate mitosis.