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Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli

M P Price1, H Gong, M G Parsons

  • 1Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Genes, Brain, and Behavior
|November 22, 2013
PubMed
Summary

Acid-sensing ion channels (ASICs) like ASIC1 and ASIC2 are crucial for brain function and defensive behaviors. Disrupting ASIC1 or ASIC2 in mice altered fear responses and increased immobility, suggesting a role in processing aversive stimuli.

Keywords:
ASIC1ASIC2Acid-sensing ion channelbraincarbon dioxidefear conditioningimmunocytochemistry

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