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Bone healing with oxytocin-loaded microporous β-TCP bone substitute in ectopic bone formation model and
Jin-Woo Park1, Jae-Min Kim, Heon-Jin Lee
1Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Aim:
This study investigated the efficacy of the hypothalamic nonapeptide oxytocin (OT) by direct delivery to local defects using a microporous β-tricalcium phosphate (TCP) as the carrier for the future applications as a method to achieve predictable bone regeneration of large osseous defects requiring sinus bone graft and guided bone regeneration procedures for implant placement.
Material And Methods:
Both the ectopic and new bone formation induced by the OT-loaded microporous β-TCP powder was histomorphometrically compared with unloaded β-TCP in a subcutaneous ectopic bone formation model and calvarial critical-sized defects (CSDs) in 45 rats.
Results:
The OT-loaded β-TCP clearly enhanced ectopic bone formation compared with the unloaded control group. A High initial OT dose (250 μg) significantly increased ectopic bone formation at an early healing time-point compared with a lower OT dose (50 μg). The OT-loaded samples displayed greater new bone formation in the rat calvarial CSDs. Extensive new bone formation was achieved in the calvarial CSDs with the higher OT dose.
Conclusion:
These results suggest that local OT delivery to bone substitute promotes new bone formation via an osteoinductive mode of action.
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