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Triterpenoids and steroids from Ganoderma mastoporum and their inhibitory effects on superoxide anion generation and
Tran Dinh Thang1, Ping-Chung Kuo, Tsong-Long Hwang
1Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam. tswu@mail.ncku.edu.tw.
Abstract:
The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
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